Minimal Tacrolimus Systemic Exposure

Minimal systemic exposure following topical application⁷:
- Most patients did not have detectable levels after topical administration ^2,7,12
- When detected, levels were transient
- Systemic tacrolimus exposure in adult eczema patients treated with Protopic Ointment was approximately 30-fold less than that seen with oral immunosuppressive doses in transplant patients⁷
No systemic accumulation⁷
Pediatric eczema patients had a lower frequency and lower average of detectable blood levels compared to adults⁴
Systemic exposure generally declined as skin returned to normal
Protopic should not be used with occlusive dressings
The use of Protopic on patients with Netherton’s syndrome or similar skin diseases is not recommended

Protopic